Protein Details: Potassium channel subfamily K member 3

Protein ID

ICDB_Pro_0203

Protein Name

Potassium channel subfamily K member 3

Gene Name

Kcnk3; Ctbak; Task; Task1

Organism

Mus musculus (Mouse)

Length

409 amino acids

AlphaFoldDB

AF-O35111-F1-model_v4.pdb

Function

pH-dependent; voltage-insensitive; background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high; current is inward.

Sequence

MKRQNVRTLALIVCTFTYLLVGAAVFDALESEPEMIERQRLELRQLELRARYNLSEGGYEELERVVLRLKPHKAGVQWRFAGSFYFAITVITTIGYGHAAPSTDGGKVFCMFYALLGIPLTLVMFQSLGERINTFVRYLLHRAKRGLGMRHAEVSMANMVLIGFVSCISTLCIGAAAFSYYERWTFFQAYYYCFITLTTIGFGDYVALQKDQALQTQPQYVAFSFVYILTGLTVIGAFLNLVVLRFMTMNAEDEKRDAEHRALLTHNGQAVGLGGLSCLSGSLGDGVRPRDPVTCAAAAGGVGVGVGGSGFRNVYAEVLHFQSMCSCLWYKSREKLQYSIPMIIPRDLSTSDTCVEHSHSSPGGGGRYSDTPSHPCLCSGTQRSAISSVSTGLHSLAAFRGLMKRRSSV

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Very strong expression in heart; also detected in kidney; brain; skin; testis; lung; skeletal muscle; small intestine and stomach. Not detected in liver; thymus or spleen.

DOI ID

10.1161/01.res.82.4.513; 10.1074/jbc.m001948200; 10.1093/emboj/16.17.5464; 10.1016/j.cell.2010.12.001

RefSeq

NP_034738.1